Stab2 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comStab2 Polyclonal Antibody for Rat(Rattus norvegicus)

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Index > Protein center > Stab2(Gene name) > Rat

Stab2 (Gene name),

Stabilin-2 (Protein name ), STAB2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Stab2(Feel2;Hare);

Protein name:

Stabilin-2;

Alternative:

Hyaluronan receptor for endocytosis;Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2(FEEL-2);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with GULP1, heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X).

Function:

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 175 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

Subcellular Location:

Cytoplasm Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1431

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1431:

LENRIWRTAT | LWGHCGPDMR | SQQATTVTVP | R

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF12947

Pfam:

PF02469

UniGene:

Rn.127827

Uniprot:

Q8CFM6

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ELISA Kit for Rat Stabilin-2

Cat.:

E0466r

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96T

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ELISA Kit for Rat Stabilin-2

Cat.:

E0466h

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96T

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ELISA Kit for Rat Stabilin-2

Cat.:

E0466m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Stabilin-2

Cat.:

U0466r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Stabilin-2

Cat.:

U0466h

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MSDS:

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Packing:

96T

CLIA Kit for Rat Stabilin-2

Cat.:

U0466m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Stabilin-2

Cat.:

P0466Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Stabilin-2

Cat.:

P0466Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Stabilin-2

Cat.:

P0466Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Stabilin-2

Protein for Rat Stabilin-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and functional expression of the rat 175-kDa hyaluronan receptor for endocytosis."
Zhou B. , Weigel J.A. , Saxena A. , Weigel P.H.
Mol. Biol. Cell13:2853-2868(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-18; 62-73; 103-120; 122-136; 488-509; 604-619; 651-668; 1070-1075 AND 1120-1129;FUNCTION
strain: Sprague-Dawley.
tissue: Endothelial cell.
2.

"Identification of a 175 kDa protein as the ligand-binding subunit of the rat liver sinusoidal endothelial cell hyaluronan receptor."
Yannariello-Brown J. , Zhou B. , Weigel P.H.
Glycobiology7:15-21(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
3.

"Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding."
Hansen B. , Longati P. , Elvevold K. , Nedredal G.-I. , Schledzewski K. , Olsen R. , Falkowski M. , Kzhyshkowska J. , Carlsson F. , Johansson S. , Smedsroed B. , Goerdt S. , Johansson S. , McCourt P.
Exp. Cell Res.303:160-173(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
4.

"Involvement of signaling of VEGF and TGF-beta in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells."
Yoshida M. , Nishikawa Y. , Omori Y. , Yoshioka T. , Tokairin T. , McCourt P. , Enomoto K.
Cell Tissue Res.329:273-282(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins."
Harris E.N. , Baggenstoss B.A. , Weigel P.H.
Am. J. Physiol.296:G1191-G1199(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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